Antifibrotic effect of methylated quercetin derivatives on TGFβ-induced hepatic stellate cells
نویسندگان
چکیده
منابع مشابه
Thunbergia laurifolia Exhibits Antifibrotic Effects in Human Hepatic Stellate Cells
Leaves of Thunbergia laurifolia (TL) have been reported to have antioxidation, anti-inflammatory, detoxifying, and hepatoprotective effects. However, studies relating to antifibrotic activity have not been reported. Currently, there is no standard treatment for hepatic fibrosis. This study aimed to investigate the antifibrotic activity of TL in human hepatic stellate LX-2 cells. Results from ce...
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Liver fibrosis is a chronic disorder that is characterized by an alteration of the balance between fibrogenesis and fibrinolysis, which results in accumulation of excessive amounts of extracellular matrix (ECM) and distortion of the normal liver architecture. The activation and transformation of quiescent hepatic stellate cells (HSCs) into myofibroblast-like cells constitute a major mechanism f...
متن کاملAntifibrotic effects of tetrandrine on hepatic stellate cells and dimethylnitrosamine-intoxicated rats
Tetrandrine (C38H42O8N2, molecular weight: 622, Tet), an alkaloid isolated from the Chinese medicinal herb Stephania tetrandra, has been shown to elicit anti-inflammatory activity in pulmonary diseases and anti-fibrotic effects in various cell types. In this study, we investigated the in vitro and in vivo effects of Tet on hepatic fibrosis. A cell line of rat hepatic stellate cells (HSC-T6) was...
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چکیده اثر عصاره آبی سیر بر درد ناشی از آزمون فرمالین در موش صحرایی نر به کوشش نرگس اسکندری روزبهانی زمینه و هدف: گیاه سیر از خانواده لیلیاسه و گونهallium sativum بومی آسیای میانه بوده و از دوران ،باستان تاکنون به خواص درمانی متفاوت آن مثل: کاهندگی قندخون، کلسترول خون، فشار خون، اثرات مفیدآن بر دستگاه قلبی عروقی و بیماریهای انعقادی خون، اثرات آنتی اکسیداتیو، درمان بیماریهای تنفسی وگوارشی، ا...
15 صفحه اولInhibitory Effect of Tanshinone IIA on Rat Hepatic Stellate Cells
BACKGROUND Anti-inflammation via inhibition of NF-κB pathways in hepatic stellate cells (HSCs) is one therapeutic approach to hepatic fibrosis. Tanshinone IIA (C19H18O3, Tan IIA) is a lipophilic diterpene isolated from Salvia miltiorrhiza Bunge, with reported anti-inflammatory activity. We tested whether Tan IIA could inhibit HSC activation. MATERIALS AND METHODS The cell line of rat hepatic ...
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ژورنال
عنوان ژورنال: Biochemistry and Biophysics Reports
سال: 2019
ISSN: 2405-5808
DOI: 10.1016/j.bbrep.2019.100678